Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FADS1 | O60427 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652665 | 0.85 | MEN1 (0.40) | DYRK1ANPC1ALDH1A1GAARAB9A | |
| SCHEMBL4086452 | 0.84 | MAPK1 (0.46) | DYRK1AMAPK1TTKWNT1NPC1 | |
| SCHEMBL651126 | 0.84 | NPC1 (0.41) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL4088328 | 0.83 | MAPK1 (0.41) | DYRK1AMAPK1TTKWNT1NPC1 | |
| SCHEMBL4088806 | 0.83 | HSD17B13 (0.42) | DYRK1AMAPK1TTKNPC1RAB9A | |
| SCHEMBL4083945 | 0.80 | MAPK1 (0.45) | DYRK1AMAPK1WNT1SCN9ANPC1 | |
| SCHEMBL4088568 | 0.80 | CDK2 (0.40) | DYRK1ATTKSCN9ANPC1RAB9A | |
| SCHEMBL4092150 | 0.80 | SMN1; SMN2 (0.40) | DYRK1AMAPK1WNT1SCN9ANPC1 | |
| SCHEMBL4078233 | 0.79 | AURKA (0.54) | JAK2 | |
| SCHEMBL655164 | 0.78 | AURKA (0.42) | MAPK1NPC1ALDH1A1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |