Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 4/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652871 | 0.74 | ALPL (0.43) | GPR35KMT2APOLBMAPT | |
| SCHEMBL4088691 | 0.73 | HCAR2 (0.33) | HCAR2DAO | |
| SCHEMBL4088696 | 0.69 | GPR35 (0.33) | GPR35PIM1DAOKMT2A | |
| SCHEMBL28589567 | 0.66 | GPR35 (0.44) | GPR35PIM1PIM2MEN1KMT2A | |
| SCHEMBL3954538 | 0.59 | PIM1 (0.40) | HCAR2GPR35PIM1PIM2DAO | |
| SCHEMBL16085090 | 0.58 | ALDH1A1 (0.41) | GPR35PIM1DAOKMT2APOLB | |
| SCHEMBL23804707 | 0.57 | DAO (0.43) | GPR35PIM1PIM2DAOKMT2A | |
| SCHEMBL18096283 | 0.55 | MCL1 (0.43) | GPR35PIM1PIM2DAO | |
| SCHEMBL28038426 | 0.55 | — | — | |
| SCHEMBL11737816 | 0.55 | KDM5A (0.48) | MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |