Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.44 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088779 | 1.00 | CHRNB2 (0.44) | CHRNB2CHRNA7CHRNA4CHRNA5BRD4 | |
| Hydrochloric Acid SCHEMBL21801537 | 0.98 | CHRNB2 (0.43) | CHRNB2CHRNA7CHRNA4CHRNA5BRD4 | |
| SCHEMBL24872393 | 0.95 | CYP1A2 (0.44) | CHRNB2CHRNA7CHRNA4CHRNA5BRD4 | |
| SCHEMBL27325877 | 0.84 | CHRNB2 (0.43) | CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL13662774 | 0.84 | CHRNB2 (0.43) | CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL15781609 | 0.80 | EPHX2 (0.40) | CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL336170 | 0.80 | CHRNB2 (0.45) | CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL336171 | 0.80 | CHRNB2 (0.45) | CHRNB2CHRNA7CHRNA4CHRNA5 | |
| SCHEMBL6922946 | 0.80 | SMN1; SMN2 (0.45) | BRD4 | |
| SCHEMBL863635 | 0.80 | SMN1; SMN2 (0.45) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115093355-B | Preparation method of pyrrole ester compound | 河南农业大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-116239822-A | Preparation method of polymer flame retardant | 合肥安邦化工有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-115093355-A | Preparation method of pyrrole ester compound | 河南农业大学 | 2022-09-23 | — | — | CN | disclosed |
| CN-110655482-A | Preparation method of gulconine | 四川轻化工大学 | 2020-01-07 | — | — | CN | disclosed |
| US-20090270425-A1 | 3-(DIHYDRO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)-4-PROPOXYBENZENESULFONAMIDE DERIVATIVES AND METHODS OF USE | CONCERT PHARMACEUTICALS INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-20090270425-A1 | 3-(DIHYDRO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)-4-PROPOXYBENZENESULFONAMIDE DERIVATIVES AND METHODS OF USE | CONCERT PHARMACEUTICALS INC. (US) | 2009-10-29 | — | — | US | disclosed |
| WO-2009099620-A1 | 3-(DIHYDRO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)-4-PROPOXYBENZENESULFONAMIDE DERIVATIVES AND METHODS OF USE | CONCERT PHARMACEUTICALS INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| US-20090203763-A1 | SUBSTITUTED BENZHYDRYLETHERS | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090197899-A1 | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use | CONCERT PHARMACEUTICALS INC. (US) | 2009-08-06 | — | — | US | disclosed |
| US-20090197899-A1 | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use | CONCERT PHARMACEUTICALS INC. (US) | 2009-08-06 | — | — | US | disclosed |
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270425-A1 | 3-(DIHYDRO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)-4-PROPOXYBENZENESULFONAMIDE DERIVATIVES AND METHODS OF USE | PDE5A, PDE3A, PDE3B | CHRNB2 2546/4885CHRNA7 2138/4885CHRNA4 1971/4885 |
| US-20090203763-A1 | SUBSTITUTED BENZHYDRYLETHERS | UGT2B7, CYP3A7, CYP3A43 | CHRNB2 3462/4885CHRNA7 2834/4885CHRNA4 3927/4885 |
| US-20090197899-A1 | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use | PDE5A, PDE3A, PDE3B | CHRNB2 2546/4885CHRNA7 2138/4885CHRNA4 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.