Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3769980 | 1.00 | HTR6 (0.33) | HTR6SIGMAR1KDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL968097 | 0.89 | HTR6 (0.39) | HTR6 | |
| Hydrochloric Acid SCHEMBL964733 | 0.79 | HTR2A (0.37) | HTR6SIGMAR1KDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL1538529 | 0.79 | HTR2A (0.37) | HTR6SIGMAR1KDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL3770251 | 0.72 | SIGMAR1 (0.34) | HTR6SIGMAR1KDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL966779 | 0.72 | HTR6 (0.33) | HTR6SIGMAR1KDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL4089813 | 0.71 | KDM4E (0.34) | HTR6SIGMAR1KDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL7935487 | 0.70 | HTR2A (0.34) | HTR6SIGMAR1KDM4ELMNATP53 | |
| SCHEMBL4089817 | 0.69 | HTR6 (0.32) | HTR6SIGMAR1KDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL4089820 | 0.66 | HTR6 (0.33) | HTR6SIGMAR1KDM4EMEN1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009104785-A1 | CATALYST COMPONENT FOR POLYMERIZATION OF ETHYLENE AND PROCESS FOR PRODUCING ETHYLENE POLYMER (1) | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-08-27 | — | — | WO | disclosed |