SCHEMBL4090043

SCHEMBL4090043

Nc1ccc(CF)cc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1338455 0.83 HRH3 (0.35)
SCHEMBL21540700 0.77 TAAR1 (0.64)
SCHEMBL5511632 0.77 GFER (0.68)
SCHEMBL18087084 0.77 GFER (0.68)
SCHEMBL1646200 0.75 LOXL2 (0.60)
SCHEMBL3482833 0.73 GFER (1.00)
4,4'-Methylenedianiline SCHEMBL28001 0.73 CYP3A4 (1.00)
SCHEMBL8094139 0.73 CYP3A4 (1.00)
SCHEMBL3482770 0.73 CYP3A4 (1.00)
SCHEMBL6362775 0.73 CYP3A4 (1.00)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170131-A1 Agents for Imaging Apoptosis BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2009-07-02 US claimed
WO-2007134127-A2 AGENTS FOR IMAGING APOPTOSIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2007-11-22 WO claimed
CN-119143751-A N-ortho-acyl substituted nitrogen-containing heterocyclic compound and preparation method of amine-shrinking iron (II) complex thereof 中国石油化工股份有限公司 2024-12-17 CN disclosed
CN-118812994-A Salicylaldehyde Schiff base/epoxy resin composite material and preparation method and application thereof 安徽省东超科技有限公司 2024-10-22 CN disclosed
CN-117624194-A KRAS G12D inhibitor and application thereof in medicine 贝达药业股份有限公司 2024-03-01 CN disclosed
US-20240051916-A1 METHOD FOR PRODUCING N-(HETERO)ARYL (METH)ACRYLAMIDE COMPOUND FUJIFILM CORPORATION (JP) 2024-02-15 US disclosed
US-20220096485-A1 FUNCTIONALIZED PYRANO[2,3-D]PYRIMIDIN-7-ONE DERIVATIVES AND METHODS FOR THEIR PREPARATION AND USE THE TEXAS A&M UNIVERSITY SYSTEM (US) 2022-03-31 US disclosed
CN-113527211-A Styryl-containing phenanthroimidazole luminescent material and preparation method and application thereof 怀化学院 2021-10-22 CN disclosed
US-11136333-B2 Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use THE TEXAS A&M UNIVERSITY SYSTEM (US) 2021-10-05 US disclosed
WO-2017205432-A1 FUNCTIONALIZED PYRANO[2,3-D]PYRIMIDIN-7-ONE DERIVATIVES AND METHODS FOR THEIR PREPARATION AND USE LU DAI (US) 2017-11-30 WO disclosed
EP-2343299-B9 Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors INCYTE HOLDINGS CORP (US) 2017-03-08 EP disclosed
US-20090253683-A1 7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF ASUBIO PHARMA CO., LTD (JP) 2009-10-08 US disclosed
US-20090170131-A1 Agents for Imaging Apoptosis BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2009-07-02 US disclosed
US-20090170131-A1 Agents for Imaging Apoptosis BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2009-07-02 US disclosed
US-20080167347-A1 Antidiabetic, antiproliferative, anticancer agents; benzanilide derivatives SHIONGI & CO., LTD. (JP) 2008-07-10 US disclosed
WO-2007134127-A3 AGENTS FOR IMAGING APOPTOSIS UNIV TEXAS (US) 2008-01-17 WO disclosed
WO-2007134127-A2 AGENTS FOR IMAGING APOPTOSIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2007-11-22 WO disclosed
WO-2007134127-A2 AGENTS FOR IMAGING APOPTOSIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2007-11-22 WO disclosed
US-5059731-A Selectively hydrogenating acetylenic and diolefinic hydrocarbons EUROPEANE DE RETRAITEMENT DE CATALYSEURS EURECAT (FR) 1991-10-22 US disclosed
US-4983559-A CATALYTIC REGENERATION EUROPEENE DE RETRAITEMENT DE CATALYSEURS EURECAT (FR) 1991-01-08 US disclosed