Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 8/20 | 0.45 |
| ▸ | CTSS | P25774 | 11/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2980722 | 0.82 | CTSS (0.47) | KCNK3CTSSCREBBP | |
| SCHEMBL2975992 | 0.82 | CTSS (0.47) | KCNK3CTSSCREBBP | |
| SCHEMBL5123995 | 0.81 | CTSS (0.44) | KCNK3CTSSCREBBP | |
| SCHEMBL4090184 | 0.77 | CTSS (0.49) | CTSS | |
| SCHEMBL4085391 | 0.76 | MAPK1 (0.48) | CREBBP | |
| SCHEMBL2973788 | 0.74 | KCNK3 (0.68) | KCNK3CTSSCREBBP | |
| SCHEMBL2969873 | 0.70 | CTSS (0.61) | KCNK3CTSSCREBBP | |
| SCHEMBL5131616 | 0.70 | CTSS (0.46) | KCNK3CTSSCREBBP | |
| SCHEMBL4714701 | 0.70 | KCNK3 (0.57) | KCNK3CTSSCREBBP | |
| SCHEMBL4712483 | 0.70 | KCNK3 (0.57) | KCNK3CTSSCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118274-A1 | MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
| US-20080269241-A1 | BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269241-A1 | BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | KCNK3 2051/4885CTSS 1/4885CREBBP 2550/4885 |
| US-20090118274-A1 | MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | KCNK3 2150/4885CTSS 1/4885CREBBP 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.