Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.47 |
| ▸ | JAK3 | P52333 | 8/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.45 |
| ▸ | AURKA | O14965 | 5/20 | 0.45 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090615 | 1.00 | JAK2 (0.47) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4094616 | 0.87 | JAK2 (0.51) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL3985659 | 0.87 | JAK2 (0.51) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4091213 | 0.86 | JAK3 (0.43) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4091209 | 0.86 | JAK3 (0.43) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4159933 | 0.83 | IGF1R (0.39) | NTRK1IGF1RFLT3FGFR1KDR | |
| SCHEMBL5103722 | 0.73 | IGF1R (0.63) | NTRK1IGF1RNTRK2FGFR1KDR | |
| SCHEMBL3985665 | 0.70 | IGF1R (0.47) | NTRK1AURKAIGF1RFGFR1KDR | |
| SCHEMBL4169882 | 0.70 | HTR7 (0.39) | NTRK1IGF1RFGFR1KDRKCNH2 | |
| SCHEMBL4158014 | 0.70 | IGF1R (0.39) | NTRK1IGF1RFGFR1KDRYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |