Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.43 |
| ▸ | JAK2 | O60674 | 9/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | MUSK | O15146 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | GRK6 | P43250 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091209 | 1.00 | JAK3 (0.43) | JAK3JAK2NTRK1CDK2LCK | |
| SCHEMBL3985659 | 0.87 | JAK2 (0.51) | JAK3JAK2NTRK1LCKRET | |
| SCHEMBL4094616 | 0.87 | JAK2 (0.51) | JAK3JAK2NTRK1LCKRET | |
| SCHEMBL4090615 | 0.86 | JAK2 (0.47) | JAK3JAK2NTRK1CDK2LCK | |
| SCHEMBL4090625 | 0.86 | JAK2 (0.47) | JAK3JAK2NTRK1CDK2LCK | |
| SCHEMBL3985665 | 0.71 | IGF1R (0.47) | NTRK1AURKAGRK6IGF1RFGFR1 | |
| SCHEMBL4159933 | 0.70 | IGF1R (0.39) | NTRK1FLT3IGF1RFGFR1KDR | |
| SCHEMBL4169882 | 0.68 | HTR7 (0.39) | NTRK1IGF1RFGFR1KDRKCNH2 | |
| SCHEMBL4033236 | 0.67 | IGF1R (0.57) | IGF1RFGFR1KDR | |
| Hydrochloric Acid SCHEMBL4173570 | 0.66 | MAPK14 (0.36) | NTRK1AURKAGRK6IGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |