Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | WEE1 | P30291 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099405 | 0.91 | HTR2A (0.35) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4105720 | 0.87 | KDM4E (0.35) | KDM4ECHEK1WEE1CDK1ALDH1A1 | |
| SCHEMBL4097169 | 0.86 | KDM4E (0.39) | KDM4ECHEK1WEE1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4091852 | 0.86 | KDM4E (0.36) | KDM4ECHEK1WEE1ALDH1A1MAPT | |
| SCHEMBL4090997 | 0.85 | KDM4E (0.36) | KDM4ECHEK1WEE1CDK1ALDH1A1 | |
| SCHEMBL4103520 | 0.83 | KDM4E (0.39) | KDM4ECHEK1WEE1ALDH1A1MAPT | |
| SCHEMBL4091069 | 0.83 | TP53 (0.40) | KDM4ECHEK1WEE1CDK1ALDH1A1 | |
| SCHEMBL4046122 | 0.79 | CACNA1B (0.43) | KDM4EALDH1A1SMN1; SMN2CACNA1HCACNA1B | |
| SCHEMBL5242696 | 0.79 | HTR1B (0.41) | KDM4EHTR7HTR1BPTPN1HRH1 | |
| SCHEMBL4044507 | 0.78 | PDK2 (0.43) | KDM4EALDH1A1SMN1; SMN2CACNA1HCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB (HR) | 2009-09-03 | — | — | US | claimed |
| EP-1846414-A1 | TETRACYCLIC MONOAMINE REUPTAKE INHIBITORS FOR TREATMENT OF CNS DISEASES AND DISORDERS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-10-24 | — | — | EP | claimed |
| WO-2006109190-A1 | TETRACYCLIC MONOAMINE REUPTAKE INHIBITORS FOR TREATMENT OF CNS DISEASES AND DISORDERS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (US) | 2006-10-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | MAOB, MAOA, TPH1 | KDM4E 1376/4885CHEK1 4696/4885WEE1 1779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.