Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091852 | 0.93 | KDM4E (0.36) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL4090997 | 0.92 | KDM4E (0.36) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL4091069 | 0.90 | TP53 (0.40) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL4103520 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1GAAHPGDCHEK1 | |
| SCHEMBL4090920 | 0.86 | KDM4E (0.36) | KDM4EALDH1A1SMN1; SMN2CHEK1WEE1 | |
| SCHEMBL4105720 | 0.85 | KDM4E (0.35) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Citric Acid SCHEMBL4109472 | 0.84 | KDM4E (0.38) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL4044268 | 0.79 | CACNA1B (0.45) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL4099405 | 0.77 | HTR2A (0.35) | KDM4EALDH1A1TDP1 | |
| SCHEMBL5242696 | 0.77 | HTR1B (0.41) | KDM4EHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB (HR) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | MAOB, MAOA, TPH1 | KDM4E 1376/4885ALDH1A1 469/4885GAA 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.