Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083540 | 0.90 | FGFR1 (0.50) | FLT3NPC1RAB9AGPR35HDAC6 | |
| SCHEMBL4088594 | 0.88 | GPR35 (0.55) | NPC1RAB9AGPR35HDAC6 | |
| SCHEMBL4091567 | 0.85 | AURKA (0.48) | FLT3KITNPC1RAB9AATM | |
| SCHEMBL4082126 | 0.85 | HDAC6 (0.48) | NPC1RAB9AGPR35HDAC6HTT | |
| SCHEMBL3879252 | 0.84 | GPR35 (0.45) | FLT3NPC1RAB9AGPR35HDAC6 | |
| SCHEMBL4092896 | 0.84 | HDAC6 (0.51) | FLT3NPC1RAB9AGPR35HDAC6 | |
| SCHEMBL4091914 | 0.83 | SMN1; SMN2 (0.51) | FLT3NPC1RAB9AGPR35HDAC6 | |
| SCHEMBL2913699 | 0.82 | GPR35 (0.51) | NPC1RAB9AATMGPR35HTT | |
| SCHEMBL4081310 | 0.81 | GPR35 (0.52) | FLT3NPC1RAB9AGPR35HDAC6 | |
| SCHEMBL4084078 | 0.79 | KIT (0.57) | FLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |