Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4093020 | 0.86 | CDC7 (0.44) | GPR35CDC7MAP4K4PIM1CDK2 | |
| SCHEMBL2904998 | 0.83 | GPR35 (0.47) | GPR35NPC1RAB9AHPGDRXFP1 | |
| SCHEMBL651126 | 0.83 | NPC1 (0.41) | ADORA3ADORA2ANPC1RAB9AMAPT | |
| SCHEMBL4088612 | 0.83 | NPC1 (0.48) | GPR35NPC1RAB9AMAPTTP53 | |
| SCHEMBL13211583 | 0.81 | KDM4E (0.37) | GPR35CDC7MAP4K4PIM1CDK2 | |
| SCHEMBL2913699 | 0.81 | GPR35 (0.51) | GPR35NPC1RAB9AMAPTRXFP1 | |
| SCHEMBL4083540 | 0.81 | FGFR1 (0.50) | GPR35CDC7MAP4K4PIM1CDK2 | |
| SCHEMBL2912045 | 0.81 | CYP1A2 (0.42) | GPR35TP53HPGDALDH1A1 | |
| SCHEMBL4088594 | 0.80 | GPR35 (0.55) | GPR35CDK2NPC1RAB9AMEN1 | |
| SCHEMBL651209 | 0.80 | CYP1A2 (0.46) | GPR35NPC1RAB9AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |