Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655164 | 0.87 | AURKA (0.42) | NPC1AURKARAB9ASMN1; SMN2 | |
| SCHEMBL4083477 | 0.87 | AURKA (0.42) | NPC1AURKARAB9AMAPTPKM | |
| SCHEMBL4091966 | 0.86 | GPR35 (0.54) | CDC7MAP4K4PIM1CDK2GSK3B | |
| SCHEMBL652230 | 0.86 | RXFP1 (0.42) | GPR35AURKARXFP1 | |
| SCHEMBL4088217 | 0.85 | AURKA (0.51) | CDK2AURKAROCK2ROCK1 | |
| SCHEMBL4082917 | 0.85 | AURKA (0.48) | CDK2ADORA3ADORA1GPR35NPC1 | |
| SCHEMBL653933 | 0.84 | MEN1 (0.43) | NPC1AURKARAB9ASMN1; SMN2 | |
| SCHEMBL4078482 | 0.84 | HPGD (0.46) | NPC1AURKARAB9AMAPTPKM | |
| SCHEMBL4088617 | 0.84 | CDK7 (0.46) | CDC7MAP4K4CDK2HIPK2NPC1 | |
| SCHEMBL653327 | 0.84 | AURKA (0.40) | AURKARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |