Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.49 |
| ▸ | CDK7 | P50613 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913699 | 0.92 | GPR35 (0.51) | FGFR1FGFR3FGFR2GPR35CDK7 | |
| SCHEMBL4081022 | 0.90 | FLT3 (0.50) | FGFR1FGFR3FGFR2GPR35HDAC6 | |
| SCHEMBL3879252 | 0.89 | GPR35 (0.45) | FGFR1FGFR3FGFR2GPR35CDK7 | |
| SCHEMBL4092896 | 0.89 | HDAC6 (0.51) | GPR35CDK7HDAC6CCNA2CDK2 | |
| SCHEMBL4088652 | 0.88 | JAK2 (0.49) | GPR35CDK7HDAC6JAK2JAK1 | |
| SCHEMBL4088257 | 0.88 | AURKA (0.47) | FGFR1FGFR3CDK7JAK2CCNA2 | |
| SCHEMBL4081310 | 0.86 | GPR35 (0.52) | GPR35CDK7HDAC6CCNA2CDK2 | |
| SCHEMBL4088594 | 0.86 | GPR35 (0.55) | GPR35CDK7HDAC6CCNA2CDK2 | |
| SCHEMBL4091914 | 0.85 | SMN1; SMN2 (0.51) | GPR35CDK7HDAC6JAK2CCNA2 | |
| SCHEMBL4078387 | 0.85 | MAPK1 (0.48) | HDAC6HTTNPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |