Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 4/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | MGMT | P16455 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4100222 | 0.84 | IGF1R (0.48) | KDM4EIGF1RFGFR1KDRADORA2A | |
| SCHEMBL3980174 | 0.78 | IGF1R (0.56) | KDM4EIGF1RFGFR1KDR | |
| SCHEMBL27773464 | 0.73 | IGF1R (0.47) | IGF1RFGFR1KDRMEN1KMT2A | |
| SCHEMBL27997938 | 0.69 | PIK3CA (0.49) | KDM4EIGF1RFGFR1ADORA2AADORA1 | |
| SCHEMBL4016083 | 0.68 | MAOB (0.54) | MPOMGMTPTGS1PTGS2MAOB | |
| SCHEMBL19406645 | 0.67 | VNN1 (0.53) | KDM4EIGF1RFGFR1KDRADORA2A | |
| SCHEMBL4118654 | 0.66 | AURKA (0.48) | MPOPTGS1PTGS2CYP1A2GRM5 | |
| SCHEMBL4032661 | 0.64 | IGF1R (0.59) | IGF1RFGFR1KDR | |
| SCHEMBL7400760 | 0.63 | KDM4E (0.56) | KDM4EPTGS1PTGS2MAOBALDH1A1 | |
| SCHEMBL30515507 | 0.61 | FLT3 (0.45) | KDRL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |