Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189642 | 0.85 | LMNA (0.45) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL13252728 | 0.84 | ALDH1A1 (0.45) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL412564 | 0.83 | ALDH1A1 (0.44) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL17225917 | 0.83 | MAPT (0.44) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL17225918 | 0.80 | ALDH1A1 (0.53) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL10241213 | 0.77 | ALDH1A1 (0.54) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL3306339 | 0.76 | LMNA (0.50) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL408751 | 0.76 | LMNA (0.50) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL3302673 | 0.75 | ALDH1A1 (0.48) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL10189641 | 0.75 | ALDH1A1 (0.57) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059250-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | Synta Pharmaceuticals Corporation (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008033449-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-20 | — | — | WO | disclosed |