Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.57 |
| ▸ | NQO2 | P16083 | 3/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4101340 | 0.81 | BRAF (0.52) | ADORA2BNQO2ADORA2ABRAFMAPK14 | |
| SCHEMBL4097414 | 0.81 | MAPK14 (0.60) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13741474 | 0.77 | ADORA2B (0.51) | ADORA2BNQO2ADORA2ABRAFMAPK14 | |
| SCHEMBL13741481 | 0.76 | CYP19A1 (0.44) | BRAFMAPK14CYP19A1MAPK13MAPK12 | |
| SCHEMBL30066479 | 0.75 | CYP2A6 (0.58) | ADORA2BNQO2ADORA2ACYP19A1MAPT | |
| Trifluoroacetic Acid SCHEMBL4092771 | 0.71 | L3MBTL1 (0.41) | BRAFMAPK14CYP19A1MAPK13MAPK12 | |
| SCHEMBL13741397 | 0.70 | MAPK13 (0.49) | ADORA2ABRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL4098176 | 0.68 | ADORA2B (0.49) | ADORA2BNQO2ADORA2AMAPK14MAPK13 | |
| SCHEMBL15075705 | 0.67 | MAPK14 (0.70) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6168758 | 0.66 | MAPK14 (0.69) | BRAFMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | ADORA2B 4778/4885NQO2 3554/4885ADORA2A 4577/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | ADORA2B 4778/4885NQO2 3554/4885ADORA2A 4577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.