Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14649475 | 0.80 | CYP3A4 (0.47) | CYP3A4EGLN1SLC40A1RAB9ANPC1 | |
| SCHEMBL1817199 | 0.77 | EGLN1 (0.46) | CYP3A4EGLN1SLC40A1RAB9ANPC1 | |
| SCHEMBL1811504 | 0.77 | CYP3A4 (0.44) | CYP3A4EGLN1SLC40A1RAB9ANPC1 | |
| SCHEMBL19113796 | 0.76 | LMNA (0.46) | CYP3A4SLC40A1RAB9ANPC1MEN1 | |
| SCHEMBL1507742 | 0.75 | RAB9A (0.55) | CYP3A4EGLN1BCHESLC40A1RAB9A | |
| SCHEMBL10705017 | 0.74 | TRPV1 (0.49) | CYP3A4EGLN1BCHETRPV1RAB9A | |
| SCHEMBL1814575 | 0.74 | EGLN1 (0.44) | CYP3A4EGLN1RAB9ANPC1MEN1 | |
| SCHEMBL1813245 | 0.74 | EGLN1 (0.44) | CYP3A4EGLN1RAB9ANPC1MEN1 | |
| SCHEMBL2084240 | 0.73 | TRPV1 (0.50) | CYP3A4TRPV1RAB9ANPC1MEN1 | |
| SCHEMBL11759262 | 0.73 | TYR (0.49) | CYP3A4EGLN1BCHETRPV1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056823-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | Wyeth (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008024922-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | WYETH (US) | 2008-02-28 | — | — | WO | disclosed |