SCHEMBL4093530

SCHEMBL4093530

CSc1nc(N)nc(-c2ccccc2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 4/20 1.00
HSP90AB1 P08238 2/20 1.00
ADORA2A P29274 6/20 0.68
ADORA1 P30542 6/20 0.68
ADORA3 P0DMS8 3/20 0.64
ADORA2B P29275 2/20 0.64
POLB P06746 1/20 0.64
RAB9A P51151 3/20 0.58
NPC1 O15118 2/20 0.58
HTT P42858 2/20 0.58
XBP1 P17861 1/20 0.58
PAX8 Q06710 1/20 0.58
NPSR1 Q6W5P4 2/20 0.50
ALOX15 P16050 1/20 0.49
TSHR P16473 1/20 0.49
HRH4 Q9H3N8 1/20 0.47
LMNA P02545 1/20 0.45
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25604007 0.86 HSP90AA1 (0.75) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
SCHEMBL4030097 0.86 HSP90AA1 (0.74) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
SCHEMBL6309967 0.84 HSP90AA1 (0.72) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
SCHEMBL6310578 0.82 HSP90AA1 (0.70) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
SCHEMBL6314477 0.82 HSP90AA1 (0.69) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
SCHEMBL6313572 0.80 HSP90AA1 (0.67) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
SCHEMBL6316030 0.80 HSP90AA1 (0.66) HSP90AA1HSP90AB1ADORA2AADORA1NPC1
SCHEMBL6314171 0.80 NPC1 (0.72) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
SCHEMBL6314388 0.80 HSP90AA1 (0.66) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3
Benzoguanamine SCHEMBL27898 0.80 ADORA2A (1.00) HSP90AA1HSP90AB1ADORA2AADORA1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2036895-B9 HSP90 INHIBITOR CHUGAI PHARMACEUTICAL CO LTD (JP) 2013-07-10 EP disclosed
EP-2036895-B9 HSP90 INHIBITOR CHUGAI PHARMACEUTICAL CO LTD (JP) 2013-07-10 EP disclosed
EP-2036895-B1 HSP90 INHIBITOR CHUGAI PHARMACEUTICAL CO LTD (JP) 2013-01-16 EP disclosed
EP-2036895-B1 HSP90 INHIBITOR CHUGAI PHARMACEUTICAL CO LTD (JP) 2013-01-16 EP disclosed
US-8193351-B2 HSP90 inhibitor CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-06-05 US disclosed
US-8193351-B2 HSP90 inhibitor CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-06-05 US disclosed
US-8193351-B2 HSP90 inhibitor CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-06-05 US disclosed
US-20090247524-A1 HSP90 Inhibitor CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2009-10-01 US disclosed
US-20090247524-A1 HSP90 Inhibitor CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2009-10-01 US disclosed
US-20090247524-A1 HSP90 Inhibitor CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2009-10-01 US disclosed
EP-2036895-A1 HSP90 INHIBITOR CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2009-03-18 EP disclosed
EP-2036895-A1 HSP90 INHIBITOR CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2009-03-18 EP disclosed
US-6919339-B2 ABCA-1 elevating compounds CV THEAPEUTICS, INC. (US) 2005-07-19 US disclosed
EP-1341773-A2 SUBSTITUTED 1,3,5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS CV THERAPEUTICS, INC. (US) 2003-09-10 EP disclosed
US-20020128266-A1 ABCA-1 elevating compounds CV THERAPEUTICS, INC. 2002-09-12 US disclosed
WO-2002046172-A2 SUBSTITUTED 1, 3, 5-TRIAZINES AND PYRIMIDINES AS ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS CV THERAPEUTICS, INC. (US) 2002-06-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247524-A1 HSP90 Inhibitor HSP90AB1, HSP90B1, HSP90AA1 HSP90AA1 3/4885HSP90AB1 1/4885ADORA2A 4662/4885
US-20020128266-A1 ABCA-1 elevating compounds ABCD3, ABCE1, ABCB4 HSP90AA1 1676/4885HSP90AB1 1191/4885ADORA2A 275/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.