Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23092286 | 0.83 | SMN1; SMN2 (0.70) | HSP90AA1HSP90AB1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL30740045 | 0.83 | SMN1; SMN2 (0.70) | HSP90AA1HSP90AB1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL9489052 | 0.83 | SMN1; SMN2 (0.70) | HSP90AA1HSP90AB1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL4093530 | 0.82 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1TSHRNPSR1ADORA2A | |
| SCHEMBL11192075 | 0.81 | ALDH1A1 (0.46) | HSP90AA1HSP90AB1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL14523587 | 0.79 | SMN1; SMN2 (0.65) | HSP90AA1HSP90AB1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL15614062 | 0.78 | ADORA2A (0.64) | HSP90AA1HSP90AB1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL6313572 | 0.74 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1ADORA2AADORA1HTT | |
| SCHEMBL6309967 | 0.73 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1SMN1; SMN2NPSR1ADORA2A | |
| SCHEMBL5032444 | 0.73 | SMN1; SMN2 (0.73) | SMN1; SMN2TSHRNPSR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919339-B2 | ABCA-1 elevating compounds | CV THEAPEUTICS, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20020128266-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128266-A1 | ABCA-1 elevating compounds | ABCD3, ABCE1, ABCB4 | HSP90AA1 1676/4885HSP90AB1 1191/4885SMN1; SMN2 4558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.