Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4094481 | 1.00 | CCR2 (0.38) | CCR2CDK1CCNB1PRKCDMAPK1 | |
| SCHEMBL2992740 | 0.94 | DYRK3 (0.41) | CCR2CDK1CCNB1PRKCDMAPK1 | |
| SCHEMBL2992745 | 0.94 | DYRK3 (0.41) | CCR2CDK1CCNB1PRKCDMAPK1 | |
| Trifluoroacetic Acid SCHEMBL4088825 | 0.87 | DYRK3 (0.38) | CDK1CCNB1PRKCDMAPK1AURKA | |
| Trifluoroacetic Acid SCHEMBL4088822 | 0.87 | DYRK3 (0.38) | CDK1CCNB1PRKCDMAPK1AURKA | |
| SCHEMBL2987074 | 0.84 | DYRK3 (0.44) | CDK1PRKCDMAPK1CCNT1CDK9 | |
| SCHEMBL2987077 | 0.84 | DYRK3 (0.44) | CDK1PRKCDMAPK1CCNT1CDK9 | |
| Trifluoroacetic Acid SCHEMBL4095081 | 0.83 | PABPC1 (0.48) | CDK1PRKCDMAPK1DYRK3MAPT | |
| Trifluoroacetic Acid SCHEMBL4095087 | 0.83 | PABPC1 (0.48) | CDK1PRKCDMAPK1DYRK3MAPT | |
| SCHEMBL4094486 | 0.82 | CDK1 (0.37) | CCR2CDK1CCNB1PRKCDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2009-08-13 | — | — | US | disclosed |
| EP-1885362-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006127458-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | HIPK3, HIPK1, HIPK4 | CCR2 4379/4885CDK1 2193/4885CCNB1 3817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.