4-Methylesculetin

4-Methylesculetin

SCHEMBL409482

Cc1cc(=O)oc2cc(O)c(O)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 8/20 1.00
ALDH1A1 P00352 8/20 1.00
KDM4E B2RXH2 7/20 1.00
HPGD P15428 7/20 1.00
HSD17B10 Q99714 7/20 1.00
AKR1B1 P15121 3/20 1.00
CYP3A4 P08684 2/20 1.00
THRB P10828 1/20 1.00
HTT P42858 1/20 0.70
NCOA3 Q9Y6Q9 1/20 0.70
CASP1 P29466 5/20 0.62
CASP7 P55210 5/20 0.62
GAA P10253 4/20 0.62
GLA P06280 3/20 0.62
CA9 Q16790 3/20 0.62
CYP1A2 P05177 2/20 0.62
CA12 O43570 2/20 0.62
LMNA P02545 1/20 0.62
CYP2C9 P11712 1/20 0.62
UGT1A1 P22309 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Methylesculetin SCHEMBL29361762 1.00 MCL1 (1.00) MCL1ALDH1A1KDM4EHPGDHSD17B10
4-Methylesculetin SCHEMBL6839210 0.98 MCL1 (0.96) MCL1ALDH1A1KDM4EHPGDHSD17B10
4-Methylesculetin SCHEMBL27453331 0.98 ALDH1A1 (0.96) MCL1ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL24865598 0.90 ALDH1A1 (0.82) MCL1ALDH1A1KDM4EHPGDHSD17B10
4-Methylesculetin SCHEMBL6262439 0.88 MCL1 (0.78) MCL1ALDH1A1KDM4EHPGDHSD17B10
4-Methylesculetin SCHEMBL7798943 0.86 KDM4E (0.73) MCL1ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL6904172 0.85 ALDH1A1 (0.74) MCL1ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL22031603 0.85 ALDH1A1 (0.74) MCL1ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL580501 0.85 ALDH1A1 (0.74) MCL1ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL31357189 0.85 MCL1 (1.00) MCL1ALDH1A1KDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 561 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119241823-B High-molecular efficient nucleating agent and preparation method and application thereof TSINGHUA UNIVERSITY (CN) 2026-05-26 CN claimed
CN-122070479-A Ultrasonic indicating device and method for monitoring ultrasonic treatment JP实验室股份有限公司 2026-05-19 CN claimed
US-20260096569-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES APEEL TECH INC (US) 2026-04-09 US claimed
US-20250354152-A1 PHARMACEUTICAL COMPOUND FOR PREVENTION OR TREATMENT OF LIVER FIBROSIS MEDIZINISCHE HOCHSCULE HANNOVER (DE) 2025-11-20 US claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
CN-119606945-B Application of 4-methyl esculetin as potential active ingredient of XIASANGJU in preparation of medicine for preventing and treating diabetes 广州白云山星群(药业)股份有限公司 2025-05-06 CN claimed
WO-2025090061-A1 ULTRASONIC INDICATOR DEVICE AND METHOD FOR MONITORING ULTRASONICATION JP LABORATORIES, INC. (US) 2025-05-01 WO claimed
EP-4536826-A1 PHARMACEUTICAL COMPOUND FOR PREVENTION OR TREATMENT OF LIVER FIBROSIS Medizinische Hochschule Hannover (DE) 2025-04-16 EP claimed
WO-2025075611-A1 ULTRASONIC INDICATOR BASED ON EMULSION FORMATION JP LABORATORIES, INC. (US) 2025-04-10 WO claimed
CN-119606945-A Application of 4-methyl esculetin as potential active ingredient of XIASANGJU in preparation of medicine for preventing and treating diabetes 广州白云山星群(药业)股份有限公司 2025-03-14 CN claimed
CN-1159131-A Electroluminescent devices BAYER AG (DE) 1997-09-10 CN claimed
US-5663029-A DEVELOPMENT OF LATENT IMAGE, TRANSFERRING TO FORM RECORDING SHEETS, COATING A SUBSTRATE USING POLYMERS XEROX CORPORATION (US) 1997-09-02 US claimed
US-5455268-A Treating arthropathy KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1995-10-03 US claimed
EP-0290442-A4 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. CHEMEX PHARMACEUTICALS INC (US) 1990-07-03 EP claimed
EP-0290442-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-11-17 EP claimed
WO-1988003805-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-06-02 WO claimed
US-4711836-A Development of positive-working photoresist compositions OLIN HUNT SPECIALTY PRODUCTS, INC. (US) 1987-12-08 US claimed
EP-0031202-B1 NEW POLYESTER COMPOSITIONS; SHAPED ARTICLES OBTAINED FROM THEM AND PROCESSES FOR PREPARING THEM IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-10-03 EP claimed
US-4347350-A Polyester compositions containing residues of dihydroxyalkoxy coumarins IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-08-31 US claimed
EP-0031202-A2 New polyester compositions; shaped articles obtained from them and processes for preparing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-07-01 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260096569-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES CYP51A1, ERG28, NISCH MCL1 2738/4885ALDH1A1 1286/4885KDM4E 1123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.