Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4096415 | 1.00 | KDM1A (0.48) | KDM1ARORCTACR1RIPK1ESR1 | |
| SCHEMBL1096191 | 0.88 | KDM1A (0.54) | KDM1ARORCTACR1RIPK1CCR5 | |
| SCHEMBL1096468 | 0.88 | KDM1A (0.54) | KDM1ARORCRIPK1 | |
| SCHEMBL31611372 | 0.83 | TLR2 (0.38) | KDM1ARORCCCR5HRH3TLR2 | |
| SCHEMBL25785910 | 0.78 | ACHE (0.40) | HRH3TLR2TLR1 | |
| SCHEMBL4094920 | 0.77 | KDM1A (0.48) | KDM1ARORCCCR5 | |
| SCHEMBL4108855 | 0.77 | KDM1A (0.48) | KDM1ARORCCCR5 | |
| SCHEMBL4105850 | 0.77 | KDM1A (0.48) | KDM1ARORCCCR5 | |
| SCHEMBL2342856 | 0.77 | RORC (0.60) | RORCTACR1 | |
| SCHEMBL4139712 | 0.77 | USP7 (0.40) | KDM1ARORCTACR1RIPK1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1882684-B1 | PYRROLIDINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-12-10 | — | — | EP | disclosed |
| US-7585886-B2 | Pyrrolidine derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2009-09-08 | — | — | US | disclosed |
| US-20090062366-A1 | Pyrrolidine derivative or salt thereof | ASTELLAS PHARAMA INC. (JP) | 2009-03-05 | — | — | US | disclosed |
| EP-1882684-A1 | PYRROLIDINE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-01-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062366-A1 | Pyrrolidine derivative or salt thereof | CASR, CYP2R1, PTH1R | KDM1A 3301/4885RORC 1397/4885TACR1 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.