Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14373829 | 0.81 | NOTUM (0.62) | GAANOTUMNPC1RAB9AALDH1A1 | |
| Acetic Acid SCHEMBL27816256 | 0.75 | NOTUM (0.54) | NOTUMNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL181974 | 0.75 | NOTUM (0.67) | GAANOTUMNPC1RAB9AALDH1A1 | |
| SCHEMBL449742 | 0.73 | NOTUM (0.47) | NOTUMALDH1A1KDM4E | |
| SCHEMBL29367686 | 0.73 | GAA (0.48) | GAANOTUMNPC1RAB9AHDAC4 | |
| SCHEMBL448095 | 0.72 | CRBN (0.46) | NOTUMNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL5234054 | 0.71 | NCOA1 (0.50) | GAANOTUMHDAC4HDAC8DYRK1A | |
| SCHEMBL29489425 | 0.70 | CYP3A4 (0.73) | GAANOTUMHDAC4HDAC8DYRK1A | |
| SCHEMBL196765 | 0.70 | CYP3A4 (0.73) | GAANOTUMHDAC4HDAC8DYRK1A | |
| SCHEMBL28774976 | 0.70 | NPC1 (0.55) | GAANPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-04-26 | — | — | US | disclosed |
| WO-2011161035-A1 | 3-ARYL-4-(2-THIENYLMETHYLENE)-ISOXAZOL-5(4H)-ONES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | CYP4X1, CYP4Z1, TH | GAA 1296/4885NOTUM 1620/4885NPC1 3817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.