Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13730529 | 0.88 | MEN1 (0.74) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL4104268 | 0.88 | MAPK1 (0.81) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL4096383 | 0.88 | MAPK1 (1.00) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL13730228 | 0.86 | MEN1 (0.80) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL14132988 | 0.86 | MEN1 (0.67) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL4104295 | 0.86 | MEN1 (1.00) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL4105506 | 0.85 | MAPK1 (0.72) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL4935254 | 0.84 | MEN1 (1.00) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL4108561 | 0.84 | MAPK1 (0.83) | MAPK1TSHRALOX15MEN1KMT2A | |
| SCHEMBL4107398 | 0.83 | MEN1 (0.80) | MAPK1TSHRALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116555148-A | Recombinant escherichia coli for biosynthesis of bilirubin and application thereof | 浙江工业大学 | 2023-08-08 | — | — | CN | disclosed |
| US-9216983-B2 | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216983-B2 | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216983-B2 | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-22 | — | — | US | disclosed |
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM UNIVERSITY OF WASHINGTON | 2009-08-20 | — | — | US | disclosed |
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM UNIVERSITY OF WASHINGTON | 2009-08-20 | — | — | US | disclosed |
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM UNIVERSITY OF WASHINGTON | 2009-08-20 | — | — | US | disclosed |
| WO-2009082691-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | DHODH, DHFR, G6PD | MAPK1 3480/4885TSHR 4432/4885ALOX15 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.