Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | KDM1A | O60341 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4107398 | 0.89 | MEN1 (0.80) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL4105140 | 0.89 | MEN1 (0.80) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL13769182 | 0.89 | MEN1 (0.80) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL4090635 | 0.89 | MEN1 (0.80) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL13730228 | 0.89 | MEN1 (0.80) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL18118625 | 0.88 | MEN1 (0.79) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL13730214 | 0.86 | MEN1 (0.76) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL14132372 | 0.86 | MEN1 (0.76) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL13730868 | 0.86 | MEN1 (0.76) | MEN1KMT2AALDH1A1HIF1AMAPK1 | |
| SCHEMBL4106565 | 0.86 | MAPK1 (0.79) | MEN1KMT2AALDH1A1HIF1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238653-B2 | Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-01-19 | — | — | US | disclosed |
| US-9216983-B2 | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216983-B2 | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216983-B2 | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-22 | — | — | US | disclosed |
| US-20120302586-A1 | ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-11-29 | — | — | US | disclosed |
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM UNIVERSITY OF WASHINGTON | 2009-08-20 | — | — | US | disclosed |
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM UNIVERSITY OF WASHINGTON | 2009-08-20 | — | — | US | disclosed |
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM UNIVERSITY OF WASHINGTON | 2009-08-20 | — | — | US | disclosed |
| WO-2009082691-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302586-A1 | ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE | DHODH, DPYD, DLD | MEN1 3993/4885KMT2A 2350/4885ALDH1A1 128/4885 |
| US-20090209557-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY | DHODH, DHFR, G6PD | MEN1 2788/4885KMT2A 2258/4885ALDH1A1 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.