Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.85 |
| ▸ | MAPT | P10636 | 3/20 | 0.85 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.85 |
| ▸ | MEN1 | O00255 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 2/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.85 |
| ▸ | HTT | P42858 | 1/20 | 0.85 |
| ▸ | TOP2A | P11388 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15920967 | 0.93 | KDM4E (0.77) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| Diphyllin SCHEMBL30887017 | 0.92 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| Diphyllin SCHEMBL1061765 | 0.92 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| SCHEMBL17339974 | 0.91 | KDM4E (0.78) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| SCHEMBL17280352 | 0.90 | KDM4E (0.69) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| Chinensinaphthol Methyl Ether SCHEMBL30471865 | 0.87 | KDM4E (0.70) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| Chinensinaphthol Methyl Ether SCHEMBL30471940 | 0.87 | KDM4E (0.70) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| SCHEMBL23065672 | 0.87 | ALDH1A1 (0.90) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| SCHEMBL21389093 | 0.86 | ALDH1A1 (0.86) | KDM4EALDH1A1MAPTNPSR1MEN1 | |
| Taiwanin E SCHEMBL15363973 | 0.84 | MEN1 (0.82) | KDM4EALDH1A1MAPTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037913-B1 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | CSIR (ZA) | 2016-07-20 | — | — | EP | claimed |
| US-8609151-B2 | Treatment of erectile dysfunction and libido enhancement | CSIR (ZA) | 2013-12-17 | — | — | US | claimed |
| US-20090202662-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | CSIR (ZA) | 2009-08-13 | — | — | US | claimed |
| EP-2037913-B1 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | CSIR (ZA) | 2016-07-20 | — | — | EP | disclosed |
| US-9211278-B2 | Composition containing arylnaphthalene lignan derivative for preventing and/or treating dementia | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-12-15 | — | — | US | disclosed |
| US-9211278-B2 | Composition containing arylnaphthalene lignan derivative for preventing and/or treating dementia | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-12-15 | — | — | US | disclosed |
| US-20140088186-A1 | COMPOSITION CONTAINING ARYLNAPHTHALENE LIGNAN DERIVATIVE FOR PREVENTING AND/OR TREATING DEMENTIA | THE COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (ZA) | 2014-03-27 | — | — | US | disclosed |
| US-20140088186-A1 | COMPOSITION CONTAINING ARYLNAPHTHALENE LIGNAN DERIVATIVE FOR PREVENTING AND/OR TREATING DEMENTIA | THE COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (ZA) | 2014-03-27 | — | — | US | disclosed |
| US-8609151-B2 | Treatment of erectile dysfunction and libido enhancement | CSIR (ZA) | 2013-12-17 | — | — | US | disclosed |
| US-7902255-B2 | γ-butyrolactone compound and pharmaceutical composition thereof | TZU CHI BUDDHIST GENERAL HOSPITAL (TW) | 2011-03-08 | — | — | US | disclosed |
| US-20100028461-A1 | Gamma-butyrolactone compound and pharmaceutical composition thereof | TZU CHI BUDDHIST GENERAL HOSPITAL (TW) | 2010-02-04 | — | — | US | disclosed |
| US-20090202662-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | CSIR (ZA) | 2009-08-13 | — | — | US | disclosed |
| US-20090202662-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | CSIR (ZA) | 2009-08-13 | — | — | US | disclosed |
| US-20090202662-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | CSIR (ZA) | 2009-08-13 | — | — | US | disclosed |
| EP-1527784-B1 | Method for extracting antineoplastic components from Bupleurum scorzonerifolium and composition comprising lactones | BUDDHIST TZU CHI GENERAL HOSPI (TW) | 2008-12-10 | — | — | EP | disclosed |
| US-7348032-B2 | Method for extracting antineoplastic components from Bupleurum scorzonerifolium | BUDDHIST TZU CHI GENERAL HOSPITAL (TW) | 2008-03-25 | — | — | US | disclosed |
| US-7348032-B2 | Method for extracting antineoplastic components from Bupleurum scorzonerifolium | BUDDHIST TZU CHI GENERAL HOSPITAL (TW) | 2008-03-25 | — | — | US | disclosed |
| WO-2007138531-A2 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | CSIR (ZA) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100028461-A1 | Gamma-butyrolactone compound and pharmaceutical composition thereof | BRCA1, HSD3B1, HSD3B2 | KDM4E 2770/4885ALDH1A1 389/4885MAPT 1329/4885 |
| US-20140088186-A1 | COMPOSITION CONTAINING ARYLNAPHTHALENE LIGNAN DERIVATIVE FOR PREVENTING AND/OR TREATING DEMENTIA | PSEN2, PSEN1, SORT1 | KDM4E 1619/4885ALDH1A1 1896/4885MAPT 13/4885 |
| US-20090202662-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND LIBIDO ENHANCEMENT | PDE3A, PDE2A, PDE3B | KDM4E 2993/4885ALDH1A1 562/4885MAPT 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.