Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 1.00 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 7/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.40 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.40 |
| ▸ | ESRRB | O95718 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271835 | 0.85 | HSD17B1 (0.73) | HSD17B1MEN1KMT2AHSP90AB1ALDH1A1 | |
| SCHEMBL4095554 | 0.81 | HSD17B1 (0.69) | HSD17B1HSD11B1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL22631752 | 0.78 | HSD17B1 (0.64) | HSD17B1MEN1KMT2A | |
| SCHEMBL26134242 | 0.77 | HSD17B1 (0.68) | HSD17B1ESR1ESR2MEN1KMT2A | |
| SCHEMBL2720462 | 0.77 | HSD17B1 (0.68) | HSD17B1ESR1ESR2MEN1KMT2A | |
| SCHEMBL18978424 | 0.77 | HSD17B1 (0.62) | HSD17B1DCLRE1ADCLRE1BALDH1A1ALOX5 | |
| SCHEMBL2770912 | 0.75 | DCLRE1B (0.59) | HSD17B1KMT2ADCLRE1ADCLRE1B | |
| SCHEMBL27510448 | 0.75 | HSD17B1 (0.59) | HSD17B1HSD11B1DCLRE1ADCLRE1BHPGD | |
| SCHEMBL4943817 | 0.74 | HSD17B1 (0.58) | HSD17B1ESR1ESR2ESRRBESRRA | |
| SCHEMBL21132510 | 0.73 | HSD17B1 (0.57) | HSD17B1MEN1KMT2ADCLRE1ADCLRE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186900-A1 | COMPOUND | STERIX LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| US-20090186900-A1 | COMPOUND | STERIX LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| US-20090186900-A1 | COMPOUND | STERIX LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| WO-2007096647-A2 | DIARYL COMPOUNDS AS NON-STEROIDAL INHIBITORS OF 17-BETA HYDROXYSTEROID DEHYDROGENASE AND/OR STEROID SULPHATASE FOR THE TREATMENT OF OESTROGEN-RELATED DISEASES SUCH AS HORMONE DEPENDENT BREAST CANCER | STERIX LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186900-A1 | COMPOUND | HSD17B2, HSD17B11, CYP17A1 | HSD17B1 4/4885HSD11B1 11/4885ESR1 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.