Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092075 | 0.81 | USP2 (0.40) | LMNAALDH1A1TSHRCYP3A4MMP12 | |
| SCHEMBL27315559 | 0.78 | ALDH1A1 (0.40) | MEN1LMNAKMT2AALDH1A1TSHR | |
| SCHEMBL16672485 | 0.78 | ESR1 (0.45) | THRBALDH1A1TSHRCYP3A4MMP12 | |
| SCHEMBL14237001 | 0.77 | LMNA (0.48) | MEN1LMNATHRBBLMKMT2A | |
| SCHEMBL5937191 | 0.77 | HCAR2 (0.40) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL341157 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1TSHRCYP3A4 | |
| SCHEMBL29092768 | 0.76 | POLB (0.50) | KMT2AALDH1A1TSHRCYP1A2CYP2C19 | |
| SCHEMBL5579233 | 0.76 | ALDH1A1 (0.39) | MEN1LMNAKMT2AALDH1A1TSHR | |
| SCHEMBL218138 | 0.76 | HTT (0.45) | ALDH1A1TSHRCYP3A4MMP12CYP1A2 | |
| SCHEMBL19451976 | 0.76 | ALDH1A1 (0.48) | LMNAALDH1A1TSHRCYP3A4MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |