Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.39 |
| ▸ | COL1A1 | P02452 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4111744 | 0.98 | COL1A1 (0.42) | COL1A1P2RX7ACHEBCHEPREP | |
| Hydrochloric Acid SCHEMBL4108595 | 0.89 | ACHE (0.47) | COL1A1P2RX7ACHEKMT2A | |
| Hydrochloric Acid SCHEMBL4098684 | 0.84 | P2RX7 (0.44) | COL1A1P2RX7ACHEBCHEPREP | |
| Hydrochloric Acid SCHEMBL4116313 | 0.84 | P2RX7 (0.38) | COL1A1P2RX7ACHE | |
| Hydrochloric Acid SCHEMBL4114582 | 0.84 | COL1A1 (0.35) | COL1A1P2RX7ACHECASR | |
| Bromide SCHEMBL4097014 | 0.82 | COL1A1 (0.49) | COL1A1P2RX7ACHEBCHEPREP | |
| Hydrochloric Acid SCHEMBL4105925 | 0.81 | ACHE (0.38) | COL1A1P2RX7ACHEBCHE | |
| Hydrochloric Acid SCHEMBL4104497 | 0.81 | COL1A1 (0.34) | COL1A1P2RX7ACHEBCHEPREP | |
| Hydrochloric Acid SCHEMBL4116296 | 0.81 | COL1A1 (0.43) | COL1A1P2RX7ACHEBCHEPREP | |
| Hydrochloric Acid SCHEMBL4111743 | 0.81 | COL1A1 (0.47) | COL1A1P2RX7ACHEBCHEPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221829-A1 | 3,4-Dihydroisoquinolinium Salt Derivatives | HANWHA CHEMICAL CORPORATION (KR) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221829-A1 | 3,4-Dihydroisoquinolinium Salt Derivatives | KCNQ3, KCNQ1, KCNQ2 | ACHE 984/4885COL1A1 4702/4885P2RX7 2386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.