Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656224 | 0.90 | FOXO1 (0.55) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL1243848 | 0.86 | FOXO1 (0.58) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL4099035 | 0.84 | FOXO1 (0.39) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL27656226 | 0.84 | FOXO1 (0.57) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL4110428 | 0.81 | MEN1 (0.79) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL1242709 | 0.78 | FOXO1 (0.83) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL24063597 | 0.76 | FOXO1 (0.87) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL17387387 | 0.76 | FOXO1 (1.00) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL29431929 | 0.76 | FOXO1 (1.00) | FOXO1MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL1243931 | 0.75 | FOXO1 (0.66) | FOXO1MEN1GAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124617-A1 | QUINOLONE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2009-05-14 | — | — | US | disclosed |
| US-7488739-B2 | Quinolone derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2009-02-10 | — | — | US | disclosed |
| US-20060148806-A1 | Quinolone derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2006-07-06 | — | — | US | disclosed |
| EP-1650192-A1 | QUINOLONE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2006-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124617-A1 | QUINOLONE DERIVATIVE OR SALT THEREOF | THPO, ABL1, GMPS | FOXO1 4219/4885MEN1 2643/4885GAA 1758/4885 |
| US-20060148806-A1 | Quinolone derivative or salt thereof | THPO, ABL1, GMPS | FOXO1 4219/4885MEN1 2643/4885GAA 1758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.