Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4097888 | 0.86 | FOXO1 (0.60) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1243137 | 0.84 | KDM4E (0.40) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1243323 | 0.82 | MEN1 (0.75) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL27656224 | 0.82 | FOXO1 (0.55) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL27656226 | 0.82 | FOXO1 (0.57) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1243135 | 0.76 | MEN1 (0.65) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1242709 | 0.76 | FOXO1 (0.83) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1241462 | 0.76 | FOXO1 (0.46) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL24063597 | 0.74 | FOXO1 (0.87) | FOXO1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL17387387 | 0.74 | FOXO1 (1.00) | FOXO1MEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879878-B2 | such as {2-[({[7-(cyclohexylamino)-6-fluoro-4-oxo-1-[(3S)-tetrahydrofuran-3-yl]-1,4-dihydroquinolin-3-yl}carbonyl)amino]ethyl}phosphonic acid, used as platelet aggregation inhibitor and purinergic receptor (P2Y12) inhibitors; therapy for circulatory diseases involving thrombosis via platelet aggregation | ASTELLAS PHARMA INC. (JP) | 2011-02-01 | — | — | US | disclosed |