Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.41 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770378 | 0.99 | ACHE (0.44) | ACHEGPR84CYP24A1CYP27A1CYP26A1 | |
| Hydrochloric Acid SCHEMBL4103773 | 0.86 | ACHE (0.44) | ACHEGPR84CYP24A1CYP27A1CYP26A1 | |
| Hydrochloric Acid SCHEMBL4098686 | 0.85 | ACHE (0.44) | ACHEGPR84MAPTKMT2ARAB9A | |
| SCHEMBL4764316 | 0.85 | ACHE (0.45) | ACHEGPR84CYP24A1CYP27A1CYP26A1 | |
| Hydrochloric Acid SCHEMBL4109079 | 0.85 | ACHE (0.40) | ACHEGPR84CYP24A1CYP27A1CYP26A1 | |
| Hydrochloric Acid SCHEMBL4108238 | 0.84 | CYP24A1 (0.46) | ACHEGPR84CYP24A1CYP27A1CYP26A1 | |
| SCHEMBL4828302 | 0.84 | ACHE (0.45) | ACHEGPR84MAPTKMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL4109322 | 0.83 | ACHE (0.43) | ACHEGPR84CYP24A1CYP27A1CYP26A1 | |
| SCHEMBL4766748 | 0.83 | CYP24A1 (0.47) | ACHEGPR84CYP24A1CYP27A1CYP26A1 | |
| Hydrochloric Acid SCHEMBL4097040 | 0.83 | ACHE (0.42) | ACHEGPR84CYP24A1CYP27A1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221829-A1 | 3,4-Dihydroisoquinolinium Salt Derivatives | HANWHA CHEMICAL CORPORATION (KR) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221829-A1 | 3,4-Dihydroisoquinolinium Salt Derivatives | KCNQ3, KCNQ1, KCNQ2 | ACHE 984/4885GPR84 3438/4885CYP24A1 3082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.