Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | FOS | P01100 | 5/20 | 0.47 |
| ▸ | JUN | P05412 | 5/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.47 |
| ▸ | RELA | Q04206 | 5/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763594 | 0.84 | MAPT (0.63) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL15624862 | 0.81 | ALDH1A1 (0.60) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL1901370 | 0.81 | MAPT (0.59) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL31148371 | 0.81 | MAPT (0.59) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL1628005 | 0.81 | MAPT (0.67) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL14800642 | 0.80 | ALDH1A1 (0.58) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL14810384 | 0.79 | KDM4E (0.57) | MAPTALDH1A1NPC1HSD17B10KDM4E | |
| SCHEMBL541532 | 0.78 | ALDH1A1 (0.56) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL12795952 | 0.77 | ALDH1A1 (0.55) | MAPTALDH1A1NPC1HSD17B10NPSR1 | |
| SCHEMBL14590421 | 0.77 | ALDH1A1 (0.57) | MAPTALDH1A1NPC1HSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131430-A1 | PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2009-05-21 | — | — | US | disclosed |
| EP-1831215-A1 | PYRIDO[2,3-D]PYRIMIDINES AS ANTI-INFLAMATORY AGENTS | Ranbaxy Laboratories Limited (IN) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006056863-A1 | PYRIDO’2, 3-D!PYRIMIDINES AS ANTI-INFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131430-A1 | PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS | TLR1, TPMT, NOD1 | MAPT 1964/4885ALDH1A1 635/4885NPC1 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.