Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | LTB4R | Q15722 | 7/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | MITF | O75030 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426219 | 1.00 | LMNA (0.59) | LMNAHSD17B10LTB4RLTB4R2SMN1; SMN2 | |
| SCHEMBL9857653 | 0.90 | LMNA (0.46) | LMNAHSD17B10LTB4RLTB4R2SMN1; SMN2 | |
| SCHEMBL11356218 | 0.82 | PPARG (0.42) | LMNAHSD17B10GBA1 | |
| SCHEMBL10697255 | 0.81 | LMNA (0.58) | LMNAHSD17B10LTB4RLTB4R2SMN1; SMN2 | |
| SCHEMBL5114421 | 0.80 | LMNA (0.69) | LMNAHSD17B10SMN1; SMN2MITFALDH1A1 | |
| SCHEMBL12134361 | 0.80 | LMNA (0.61) | LMNAHSD17B10SMN1; SMN2MITFALDH1A1 | |
| SCHEMBL6426221 | 0.78 | GBA1 (0.61) | LMNAHSD17B10SMN1; SMN2MITFALDH1A1 | |
| SCHEMBL2058475 | 0.78 | GBA1 (0.61) | LMNAHSD17B10SMN1; SMN2MITFALDH1A1 | |
| SCHEMBL50454 | 0.78 | LMNA (0.80) | LMNAHSD17B10SMN1; SMN2MITFALDH1A1 | |
| SCHEMBL7598667 | 0.77 | ELANE (0.57) | LMNAALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484463-A1 | SELECTIVE ESTROGEN-RECEPTOR MODULATORS (SERMS) CONFER PROTECTION AGAINST PHOTORECEPTOR DEGENERATION | The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology Transfer (US) | 2019-05-22 | — | — | EP | disclosed |
| WO-2018034945-A1 | SELECTIVE ESTROGEN-RECEPTOR MODULATORS (SERMS) CONFER PROTECTION AGAINST PHOTORECEPTOR DEGENERATION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-02-22 | — | — | WO | disclosed |
| US-20090186944-A1 | PREVENTION AND TREATMENT OF BREAST CANCER WITH 4-HYDROXY TAMOXIFEN | LABORATOIRES BESINS INTERNATIONAL SA | 2009-07-23 | — | — | US | disclosed |