Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | ACR | P10323 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4100247 | 0.90 | LMNA (0.59) | LMNAHSD17B10RAB9AGBA1SMN1; SMN2 | |
| SCHEMBL6426219 | 0.90 | LMNA (0.59) | LMNAHSD17B10RAB9AGBA1SMN1; SMN2 | |
| SCHEMBL9857644 | 0.80 | GBA1 (0.60) | LMNAHSD17B10RXRARXRBRAB9A | |
| SCHEMBL11356218 | 0.77 | PPARG (0.42) | LMNAHSD17B10GBA1 | |
| SCHEMBL7998270 | 0.75 | LMNA (0.57) | LMNAHSD17B10SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7598201 | 0.74 | ABCB1 (0.50) | RAB9ASMN1; SMN2NPC1L3MBTL1ALDH1A1 | |
| SCHEMBL10697255 | 0.73 | LMNA (0.58) | LMNAHSD17B10CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL10827606 | 0.70 | LMNA (0.83) | LMNAHSD17B10SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12134361 | 0.69 | LMNA (0.61) | LMNAHSD17B10CRHBPCRHR2RAB9A | |
| SCHEMBL10828022 | 0.69 | GBA1 (0.54) | LMNAHSD17B10RAB9AGBA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272330-B1 | 1,1,2-TRIARYL-1-BUTENE DERIVATIVES | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4897503-A | ANTITUMOR AGENTS; TREATING MAMMARY CANCER AND ANOVULATORY INFERTILITY | TAIHO PHARMACEUTICAL (JP) | 1990-01-30 | — | — | US | disclosed |
| EP-0272330-A1 | 1,1,2-TRIARYL-1-BUTENE DERIVATIVES | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1988-06-29 | — | — | EP | disclosed |