Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADH1B | P00325 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | ADH7 | P40394 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410631 | 1.00 | TSHR (0.48) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL17143629 | 1.00 | TSHR (0.48) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL294760 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL15326958 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL1782642 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL23803614 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL23803613 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL23803605 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL15326982 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 | |
| SCHEMBL15326984 | 0.98 | TSHR (0.52) | TSHRFAAHTRPV1HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10711040-B2 | Low substituted polymyxins and compositions thereof | XELLIA PHARMACEUTICALS APS (DK) | 2020-07-14 | — | — | US | claimed |
| US-10640536-B2 | Polymyxins, compositions, methods of making and methods of use | XELLIA PHARMACEUTICALS APS (DK) | 2020-05-05 | — | — | US | claimed |
| EP-3166960-B1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | XELLIA PHARMACEUTICALS APS (DK) | 2019-08-07 | — | — | EP | claimed |
| CN-104918951-B | Polymyxins, composition, preparation method and application method | 埃克斯利亚制药有限公司 | 2018-03-30 | — | — | CN | claimed |
| EP-2943503-B1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS (DK) | 2017-08-23 | — | — | EP | claimed |
| US-20170218024-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | XELLIA PHARMACEUTICALS APS (DK) | 2017-08-03 | — | — | US | claimed |
| EP-3166960-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | Xellia Pharmaceuticals ApS (DK) | 2017-05-17 | — | — | EP | claimed |
| WO-2016005223-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | XELLIA PHARMACEUTICALS APS (DK) | 2016-01-14 | — | — | WO | claimed |
| US-20160002296-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS (DK) | 2016-01-07 | — | — | US | claimed |
| EP-2943503-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | Xellia Pharmaceuticals ApS (DK) | 2015-11-18 | — | — | EP | claimed |
| CN-104918951-A | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS | 2015-09-16 | — | — | CN | claimed |
| WO-2014108469-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS (DK) | 2014-07-17 | — | — | WO | claimed |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-08-27 | — | — | US | claimed |
| US-20230322858-A1 | POLYMYXIN DERIVATIVES AND THEIR USE IN COMBINATION THERAPY TOGETHER WITH DIFFERENT ANTIBIOTICS | SPERO THERAPEUTICS, INC. | 2023-10-12 | — | — | US | disclosed |
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC | 2023-04-27 | — | — | US | disclosed |
| CN-114790226-A | Antibacterial peptide and preparation method thereof | 正大天晴药业集团股份有限公司 | 2022-07-26 | — | — | CN | disclosed |
| WO-2012168820-A1 | POLYMYXIN DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2012-12-13 | — | — | WO | disclosed |
| US-8329645-B2 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS LTD. (FI) | 2012-12-11 | — | — | US | disclosed |
| US-8198058-B2 | Such as ethanol, methanol, and diesel fuels via fermenting organic waste material, converting biogas to synthesis gas comprising carbon monoxide and hydrogen by reforming and oxidation, contacting synthesis gas with catalyst to produce alcohol mixture, then purifying | TRUBLU MANAGEMENT LLC | 2012-06-12 | — | — | US | disclosed |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322858-A1 | POLYMYXIN DERIVATIVES AND THEIR USE IN COMBINATION THERAPY TOGETHER WITH DIFFERENT ANTIBIOTICS | PNISR, MRPS18A, RRP15 | TSHR 1066/4885FAAH 4346/4885TRPV1 3689/4885 |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | C5, C9, C3AR1 | TSHR 1242/4885FAAH 4373/4885TRPV1 505/4885 |
| US-20160002296-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | C5, SGMS1, SGMS2 | TSHR 2808/4885FAAH 1286/4885TRPV1 2893/4885 |
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | TLR4, TLR5, TLR1 | TSHR 4060/4885FAAH 968/4885TRPV1 2668/4885 |
| US-10640536-B2 | Polymyxins, compositions, methods of making and methods of use | C5, HRH3, SGMS1 | TSHR 2796/4885FAAH 1266/4885TRPV1 2910/4885 |
| US-20170218024-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | TLR3, TLR4, TLR5 | TSHR 4714/4885FAAH 4427/4885TRPV1 1780/4885 |
| US-10711040-B2 | Low substituted polymyxins and compositions thereof | TLR3, TLR4, TLR5 | TSHR 4714/4885FAAH 4427/4885TRPV1 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.