SCHEMBL4101257

SCHEMBL4101257

N[C@@H](CCP(=O)(O)C(O)c1cccc(C(=O)O)c1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 17/20 1.00
GRM6 O15303 6/20 0.72
GRM8 O00222 14/20 0.67
GRM7 Q14831 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4085528 0.84 GRM4 (1.00) GRM4GRM6GRM8GRM7
SCHEMBL10000470 0.81 GRM4 (1.00) GRM4GRM6GRM8GRM7
SCHEMBL8238927 0.81 GRM4 (1.00) GRM4GRM6GRM8GRM7
SCHEMBL10027481 0.80 GRM4 (0.75) GRM4GRM6GRM8
SCHEMBL4084499 0.75 GRM4 (0.67) GRM4GRM6GRM8
SCHEMBL4085076 0.74 GRM4 (0.60) GRM4GRM6GRM8GRM7
SCHEMBL13975652 0.73 GRM8 (0.73) GRM4GRM6GRM8GRM7
SCHEMBL13859024 0.73 GRM4 (0.69) GRM4GRM6GRM8
SCHEMBL13976058 0.73 GRM4 (0.69) GRM4GRM6GRM8
SCHEMBL13774890 0.73 GRM4 (1.00) GRM4GRM6GRM8GRM7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170813-A1 Hypophosphorous Acid Derivatives and their Therapeutical Applications CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) 2009-07-02 US disclosed
US-20090170813-A1 Hypophosphorous Acid Derivatives and their Therapeutical Applications CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) 2009-07-02 US disclosed
US-20090170813-A1 Hypophosphorous Acid Derivatives and their Therapeutical Applications CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) 2009-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170813-A1 Hypophosphorous Acid Derivatives and their Therapeutical Applications P4HA1, CYP2R1, EGLN3 GRM4 1497/4885GRM6 1170/4885GRM8 1667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.