Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17207198 | 0.80 | ALDH1A1 (0.56) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL4106854 | 0.78 | TRPA1 (0.49) | LMNAMAPK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17207212 | 0.77 | LMNA (0.48) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL19006515 | 0.75 | JMJD6 (0.56) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL10202654 | 0.74 | LMNA (0.58) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL1759647 | 0.74 | LMNA (0.62) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL31085231 | 0.74 | LMNA (0.58) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL4112733 | 0.73 | TRPA1 (0.44) | LMNASMN1; SMN2HTTTRPA1ALDH1A1 | |
| SCHEMBL11347447 | 0.73 | LMNA (0.56) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL17207196 | 0.70 | ALDH1A1 (0.59) | LMNAMEN1MAPK1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084471-B2 | Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides | YALE UNIVERSITY (US) | 2011-12-27 | — | — | US | disclosed |
| US-8084471-B2 | Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides | YALE UNIVERSITY (US) | 2011-12-27 | — | — | US | disclosed |
| US-8084471-B2 | Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides | YALE UNIVERSITY (US) | 2011-12-27 | — | — | US | disclosed |
| US-20090220586-A1 | PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES | YALE UNIVERSITY (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090220586-A1 | PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES | YALE UNIVERSITY (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090220586-A1 | PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES | YALE UNIVERSITY (US) | 2009-09-03 | — | — | US | disclosed |
| WO-2008030408-A2 | PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF A NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES | YALE UNIVERSITY (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090220586-A1 | PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES | NCOA1, NCOA2, NCOA3 | LMNA 3285/4885MEN1 3462/4885MAPK1 2424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.