SCHEMBL4103703

SCHEMBL4103703

COc1ccc(C(=O)c2cccc(OCc3nc(-c4ccccc4)oc3C)c2)c(O)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.60
KDR P35968 1/20 0.57
TP53 P04637 1/20 0.56
FFAR1 O14842 1/20 0.53
VDR P11473 2/20 0.53
PPARG P37231 8/20 0.53
PPARA Q07869 8/20 0.53
ALDH1A1 P00352 1/20 0.53
LMNA P02545 1/20 0.53
CYP1A2 P05177 1/20 0.53
PGR P06401 1/20 0.53
CYP2D6 P10635 1/20 0.53
HPGD P15428 1/20 0.53
SLC6A2 P23975 1/20 0.53
PDE4A P27815 1/20 0.53
MAPK1 P28482 1/20 0.53
CYP2C19 P33261 1/20 0.53
HRH1 P35367 1/20 0.53
HTT P42858 1/20 0.53
SLC6A3 Q01959 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4098230 0.92 MAPT (0.62) MAPTKDRTP53FFAR1PPARG
SCHEMBL4846832 0.91 FFAR1 (0.60) MAPTKDRTP53FFAR1PPARG
SCHEMBL4111348 0.89 MAPT (0.56) MAPTKDRTP53FFAR1VDR
SCHEMBL4103902 0.89 MAPT (0.56) MAPTKDRTP53FFAR1VDR
SCHEMBL4107208 0.89 MAPT (0.57) MAPTKDRTP53FFAR1PPARG
SCHEMBL4031901 0.87 FFAR1 (0.63) MAPTKDRFFAR1PPARGPPARA
SCHEMBL4103742 0.86 MAPT (0.53) MAPTKDRTP53FFAR1VDR
SCHEMBL4106336 0.85 MAPT (0.54) MAPTKDRTP53FFAR1PPARG
SCHEMBL4097664 0.85 FFAR1 (0.56) MAPTKDRTP53FFAR1PPARG
SCHEMBL4102149 0.85 MAPT (0.61) MAPTKDRTP53FFAR1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090054435-A1 Phenoxyalkanoic Acid Compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-02-26 US disclosed
EP-1911738-A1 PHENOXYALKANOIC ACID COMPOUND Takeda Pharmaceutical Company Limited (JP) 2008-04-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054435-A1 Phenoxyalkanoic Acid Compound PNLIP, GPR119, LIPC MAPT 3533/4885KDR 2450/4885TP53 2321/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.