Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 10/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39776 | 0.81 | FOLH1 (0.45) | FOLH1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL40066 | 0.79 | FOLH1 (0.56) | FOLH1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL576723 | 0.79 | FOLH1 (0.56) | FOLH1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL6903869 | 0.79 | ALDH1A1 (0.65) | FOLH1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL45509 | 0.77 | FOLH1 (0.50) | FOLH1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL46927 | 0.76 | FOLH1 (0.53) | FOLH1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL7282885 | 0.73 | FOLH1 (0.61) | FOLH1MRGPRX4NR4A2 | |
| SCHEMBL2705263 | 0.72 | FOLH1 (0.59) | FOLH1MRGPRX4NR4A2 | |
| SCHEMBL29471974 | 0.72 | FOLH1 (0.59) | FOLH1MRGPRX4NR4A2 | |
| SCHEMBL31044565 | 0.72 | FOLH1 (0.59) | FOLH1MRGPRX4TP53NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |