Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | MRGPRX4 | Q96LA9 | 15/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E1501 SCHEMBL16756657 | 0.86 | ALDH1A1 (0.81) | ALDH1A1RAB9A | |
| SCHEMBL6709375 | 0.85 | ALDH1A1 (0.73) | ALDH1A1RAB9A | |
| SCHEMBL28073170 | 0.84 | MRGPRX4 (0.54) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL6669706 | 0.83 | ALDH1A1 (0.56) | ALDH1A1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL46927 | 0.83 | FOLH1 (0.53) | ALDH1A1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL7892900 | 0.83 | ALDH1A1 (0.65) | ALDH1A1MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL17331104 | 0.83 | LMNA (0.62) | ALDH1A1MRGPRX4RAB9ANPC1 | |
| SCHEMBL6761544 | 0.83 | MRGPRX4 (0.57) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL30628893 | 0.82 | MRGPRX4 (0.67) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL565902 | 0.82 | MRGPRX4 (0.67) | MRGPRX4TP53PKMNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100577163-C | Compounds affecting glucokinase | ASTRAZENECA AB | 2010-01-06 | — | — | CN | disclosed |
| CN-101584691-A | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2009-11-25 | — | — | CN | disclosed |
| CN-1568185-A | Compounds affecting glucokinase | ASTRAZENECA AB (SE) | 2005-01-19 | — | — | CN | disclosed |
| EP-1043304-B1 | Method for producing (hydroxyalkyl)alicyclic carboxylic acids and intermediates therefor | NIPPON CATALYTIC CHEM IND (JP) | 2004-02-25 | — | — | EP | disclosed |
| US-6444843-B1 | CATALYTIC OXIDATION | NIPPON SHOKUBAI CO., LTD. (JP) | 2002-09-03 | — | — | US | disclosed |
| EP-1043304-A1 | Method for producing (hydroxyalkyl)alicyclic carboxylic acids and intermediates therefor | Nippon Shokubai Co., Ltd. (JP) | 2000-10-11 | — | — | EP | disclosed |
| EP-0764159-B1 | C -4 AMIDE SUBSTITUTED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-09 | — | — | EP | disclosed |
| US-5843989-A | C4 -amide substituted compounds and their use as therapeutic agents | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-12-01 | — | — | US | disclosed |
| EP-0764159-A1 | C -4 AMIDE SUBSTITUTED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995034547-A1 | C-4 AMIDE SUBSTITUTED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1995-12-21 | — | — | WO | disclosed |