Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4107010 | 1.00 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL14103261 | 0.80 | NPSR1 (0.47) | HCAR2ALDH1A1TDP1TSHRPRKCA | |
| SCHEMBL5456398 | 0.79 | NOS1 (0.34) | ALDH1A1TDP1CA2PRKCA | |
| SCHEMBL5456400 | 0.79 | NOS1 (0.34) | ALDH1A1TDP1CA2PRKCA | |
| SCHEMBL31377686 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TDP1CA2SMN1; SMN2MMP1 | |
| SCHEMBL31377801 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TDP1CA2SMN1; SMN2MMP1 | |
| SCHEMBL15482551 | 0.77 | ALDH1A1 (0.42) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL20878796 | 0.77 | ALDH1A1 (0.42) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL5458858 | 0.76 | ALDH1A1 (0.40) | ALDH1A1TDP1CA2MMP1MMP2 | |
| SCHEMBL831211 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088419-A1 | PYRIDYL ACETIC ACID COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | US | disclosed |
| EP-1851202-A1 | PYRIDYL ACETIC ACID COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006090915-A1 | PYRIDYL ACETIC ACID COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088419-A1 | PYRIDYL ACETIC ACID COMPOUNDS | DPP4, GPR119, DPP3 | HCAR2 36/4885KEAP1 2430/4885NFE2L2 2912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.