Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119705 | 0.87 | MEN1 (0.45) | CDK1SYKNPSR1HSD17B10HTT | |
| SCHEMBL658909 | 0.76 | STK17A (0.51) | SYKAURKA | |
| SCHEMBL339742 | 0.76 | SYK (0.46) | CDK1SYKMAPTPOLBAURKA | |
| SCHEMBL654408 | 0.75 | ALDH1A1 (0.47) | SYKAURKAALDH1A1BCL6 | |
| SCHEMBL3458617 | 0.75 | EGFR (0.49) | CDK1SYKROCK2ROCK1AURKA | |
| SCHEMBL655376 | 0.74 | AURKA (0.49) | CDK1SYKAURKAALDH1A1BCL6 | |
| SCHEMBL657293 | 0.74 | ROCK2 (0.61) | SYKROCK2ROCK1 | |
| SCHEMBL656017 | 0.74 | SYK (0.60) | CDK1SYKROCK2ROCK1 | |
| SCHEMBL656737 | 0.74 | SYK (0.55) | CDK1SYKAURKATRPA1ALDH1A1 | |
| SCHEMBL655569 | 0.73 | STK17A (0.43) | SYKAURKABCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063240-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF AURORA KINASE | ARROW THERAPEUTICS LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |