Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL5533372 | 0.89 | TSHR (0.62) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL23340 | 0.87 | TSHR (0.64) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL30425799 | 0.87 | TSHR (0.64) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL6964569 | 0.85 | TSHR (0.61) | TSHRCA1CA2CA7CA9 | |
| Ethylene Glycol SCHEMBL27641001 | 0.85 | TSHR (0.61) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL28584114 | 0.85 | TSHR (0.61) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL606328 | 0.83 | TSHR (0.58) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL16437099 | 0.83 | TSHR (0.58) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL12865302 | 0.83 | TSHR (0.58) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL16437096 | 0.83 | TSHR (0.58) | TSHRCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1676562-B2 | Composition for the hair containing uv filters | KAO GERMANY GMBH (DE) | 2016-03-02 | — | — | EP | disclosed |
| EP-1676562-B1 | Composition for the hair containing uv filters | KAO GERMANY GMBH (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-20090104137-A1 | COSMETIC COMPOSITION | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| WO-2007038496-A2 | SYNTHESIS OF FATTY ALCOHOL ESTERS OF HYDROXY CARBOXYLIC ACIDS, THE USE OF THE SAME AS PERCUTANEOUS PERMEATION ENHANCERS | CHEMIC LABORATORIES, INC. (US) | 2007-04-05 | — | — | WO | disclosed |
| EP-1676562-A1 | Composition for the hair containing uv filters | KPSS-Kao Professional Salon Services GmbH (DE) | 2006-07-05 | — | — | EP | disclosed |
| US-20060134030-A1 | Cosmetic composition | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060134030-A1 | Cosmetic composition | CUTA, TRPC5, H1-5 | TSHR 3675/4885CA1 1850/4885CA2 1722/4885 |
| US-20090104137-A1 | COSMETIC COMPOSITION | CUTA, TRPC5, H1-5 | TSHR 3675/4885CA1 1850/4885CA2 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.