Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | POLB | P06746 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285516 | 1.00 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL29763164 | 1.00 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL14991107 | 1.00 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL441970 | 1.00 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL411110 | 1.00 | ALDH1A1 (1.00) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL31710840 | 0.90 | ALDH1A1 (0.82) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL9741723 | 0.90 | ALDH1A1 (0.82) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL2172873 | 0.90 | ALDH1A1 (0.81) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL6896852 | 0.88 | ALDH1A1 (0.79) | ALDH1A1POLBKDM4EHPGDMAPK1 | |
| SCHEMBL6896845 | 0.88 | ALDH1A1 (0.79) | ALDH1A1POLBKDM4EHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120064004-A1 | ISOTOPOLOGUES OF THALIDOMIDE | CELGENE CORPORATION | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064004-A1 | ISOTOPOLOGUES OF THALIDOMIDE | CDK4, FKBP8, FKBP1A | ALDH1A1 1659/4885POLB 1400/4885KDM4E 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.