Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 | Q05940 | 2/20 | 0.57 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 5/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30682978 | 0.86 | CCR5 (0.53) | SLC18A2F10PRSS1USP30 | |
| SCHEMBL1896053 | 0.86 | CCR5 (0.53) | SLC18A2F10PRSS1USP30 | |
| SCHEMBL1890242 | 0.86 | F10 (0.47) | SLC18A2ALDH1A1MAPTF10PRSS1 | |
| SCHEMBL3449300 | 0.86 | RORC (0.55) | SLC18A2ALDH1A1MAPTUSP30 | |
| SCHEMBL5839366 | 0.86 | RORC (0.55) | SLC18A2ALDH1A1MAPTUSP30 | |
| SCHEMBL7887604 | 0.86 | RORC (0.55) | SLC18A2ALDH1A1MAPTUSP30 | |
| SCHEMBL1714033 | 0.81 | KDM4E (0.51) | S1PR5S1PR1SMN1; SMN2ALDH1A1USP30 | |
| SCHEMBL1714032 | 0.81 | KDM4E (0.51) | S1PR5S1PR1SMN1; SMN2ALDH1A1USP30 | |
| SCHEMBL3033370 | 0.81 | SLC18A2 (0.53) | SLC18A2USP30 | |
| SCHEMBL2782549 | 0.81 | SLC18A2 (0.53) | SLC18A2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1882684-B1 | PYRROLIDINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-12-10 | — | — | EP | disclosed |
| US-7585886-B2 | Pyrrolidine derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2009-09-08 | — | — | US | disclosed |
| US-20090062366-A1 | Pyrrolidine derivative or salt thereof | ASTELLAS PHARAMA INC. (JP) | 2009-03-05 | — | — | US | disclosed |
| EP-1882684-A1 | PYRROLIDINE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-01-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062366-A1 | Pyrrolidine derivative or salt thereof | CASR, CYP2R1, PTH1R | SLC18A2 1890/4885S1PR5 499/4885S1PR1 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.