SCHEMBL411339

SCHEMBL411339

COc1ccc(OCC(O)Cn2c3ccccc3c3ccccc32)cc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 9/20 0.80
KMT2A Q03164 6/20 0.80
MAPT P10636 5/20 0.80
MEN1 O00255 5/20 0.80
RECQL P46063 3/20 0.80
KDM4E B2RXH2 3/20 0.80
CYP1A2 P05177 2/20 0.80
CYP3A4 P08684 2/20 0.80
CYP2D6 P10635 2/20 0.80
CYP2C9 P11712 2/20 0.80
CYP2C19 P33261 2/20 0.80
NPSR1 Q6W5P4 2/20 0.80
L3MBTL1 Q9Y468 1/20 0.67
DNM1 Q05193 1/20 0.63
HTT P42858 4/20 0.63
HPGD P15428 2/20 0.63
GAA P10253 1/20 0.63
SMN1; SMN2 Q16637 3/20 0.62
TSHR P16473 1/20 0.62
GPR55 Q9Y2T6 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL411822 0.88 LMNA (1.00) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL14689199 0.85 LMNA (0.68) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL410187 0.84 MAPT (0.69) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL27846829 0.83 DNM1 (0.70) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL19547484 0.82 MAPT (0.77) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL410204 0.81 MAPT (0.56) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL410820 0.81 LMNA (1.00) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL14701126 0.80 LMNA (0.66) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL410694 0.80 MAPT (0.80) LMNAKMT2AMAPTMEN1RECQL
SCHEMBL19559285 0.79 LMNA (0.69) LMNAKMT2AMAPTMEN1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 172 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180318255-A1 Pro-Neurogenic Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2018-11-08 US claimed
EP-2590647-B1 PRO-NEUROGENIC COMPOUNDS UNIV TEXAS (US) 2017-11-08 EP claimed
US-20170157092-A1 Anti-depression Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2017-06-08 US claimed
US-20160362372-A1 PRO-NEUROGENIC COMPOUNDS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2016-12-15 US claimed
US-20160206594-A1 Pro-Neurogenic Compounds NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-07-21 US claimed
US-20160206596-A1 Anti-depression Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2016-07-21 US claimed
US-20150290195-A1 PRO-NEUROGENIC COMPOUNDS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2015-10-15 US claimed
EP-2925129-A1 PRO-NEUROGENIC COMPOUNDS Board of Regents of the University of Texas System (US) 2015-10-07 EP claimed
US-20150057301-A1 Pro-Neurogenic Compounds NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-02-26 US claimed
US-20140343018-A1 Anti-depression Compounds NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2014-11-20 US claimed
US-20130184301-A1 Methods of Treating Post-Traumatic Stress Disorder Using Pro-Neurogenic Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-07-18 US claimed
EP-2590647-A2 PRO-NEUROGENIC COMPOUNDS Board of Regents of the University of Texas System (US) 2013-05-15 EP claimed
US-20130040977-A1 Pro-Neurogenic Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2013-02-14 US claimed
US-20120022096-A1 PRO-NEUROGENIC COMPOUNDS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-01-26 US claimed
WO-2012006419-A2 PRO-NEUROGENIC COMPOUNDS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-01-12 WO claimed
EP-2385829-A1 PRO-NEUROGENIC COMPOUNDS Board of Regents of the University of Texas System (US) 2011-11-16 EP claimed
US-8039041-B2 Electroluminescent devices with electrode protection CAMBRIDGE DISPLAY TECHNOLOGY, LTD. (GB) 2011-10-18 US claimed
US-20110015217-A1 Pro-Neurogenic Compounds BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2011-01-20 US claimed
US-20110003836-A1 Pro-Neurogenic Compounds BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2011-01-06 US claimed
WO-2010081115-A1 PRO-NEUROGENIC COMPOUNDS UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) 2010-07-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130184301-A1 Methods of Treating Post-Traumatic Stress Disorder Using Pro-Neurogenic Compounds BDNF, GAP43, DCX LMNA 993/4885KMT2A 3075/4885MAPT 578/4885
US-20120022096-A1 PRO-NEUROGENIC COMPOUNDS BDNF, GAP43, DCX LMNA 174/4885KMT2A 3749/4885MAPT 136/4885
US-20160206594-A1 Pro-Neurogenic Compounds DCX, GAP43, BDNF LMNA 654/4885KMT2A 2693/4885MAPT 559/4885
US-20150057301-A1 Pro-Neurogenic Compounds DCX, GAP43, BDNF LMNA 521/4885KMT2A 2712/4885MAPT 620/4885
US-20180318255-A1 Pro-Neurogenic Compounds BDNF, GAP43, DCX LMNA 174/4885KMT2A 3749/4885MAPT 136/4885
US-20110015217-A1 Pro-Neurogenic Compounds DCX, GAP43, BDNF LMNA 654/4885KMT2A 2693/4885MAPT 559/4885
US-20150290195-A1 PRO-NEUROGENIC COMPOUNDS DCX, GAP43, BDNF LMNA 654/4885KMT2A 2693/4885MAPT 559/4885
US-20140343018-A1 Anti-depression Compounds BDNF, DCX, GAP43 LMNA 523/4885KMT2A 3598/4885MAPT 142/4885
US-20130040977-A1 Pro-Neurogenic Compounds BDNF, GAP43, DCX LMNA 174/4885KMT2A 3749/4885MAPT 136/4885
US-20110003836-A1 Pro-Neurogenic Compounds DCX, GAP43, BDNF LMNA 628/4885KMT2A 2838/4885MAPT 571/4885
US-20160362372-A1 PRO-NEUROGENIC COMPOUNDS DCX, GAP43, BDNF LMNA 654/4885KMT2A 2693/4885MAPT 559/4885
US-20160206596-A1 Anti-depression Compounds BDNF, DCX, GAP43 LMNA 523/4885KMT2A 3598/4885MAPT 142/4885
US-20170157092-A1 Anti-depression Compounds BDNF, DCX, GAP43 LMNA 523/4885KMT2A 3598/4885MAPT 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.