Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.64 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.64 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 13/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | GBA1 | P04062 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118553 | 0.88 | NPC1 (0.69) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4122903 | 0.87 | NPC1 (0.71) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4115616 | 0.86 | NPC1 (0.65) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4112443 | 0.85 | NPC1 (0.71) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4125122 | 0.85 | RAB9A (0.76) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4104506 | 0.85 | NPC1 (0.68) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL30002285 | 0.85 | MEN1 (0.68) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL30851500 | 0.85 | RAB9A (0.79) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL27193042 | 0.85 | RAB9A (0.79) | NPC1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4113845 | 0.84 | RAB9A (0.68) | NPC1KMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | NEUROGEN CORPORATION | 2009-09-24 | — | — | US | disclosed |
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | NEUROGEN CORPORATION | 2009-09-24 | — | — | US | disclosed |
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | NEUROGEN CORPORATION | 2009-09-24 | — | — | US | disclosed |
| EP-1804785-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006049941-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | CNR1, CNR2, OPRL1 | NPC1 927/4885KMT2A 2807/4885MEN1 3273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.