Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14287834 | 0.77 | PDE10A (0.38) | CDK2PDE10A | |
| SCHEMBL4111647 | 0.77 | ATM (0.32) | ATML3MBTL1TBXAS1 | |
| SCHEMBL5119212 | 0.73 | PDE10A (0.40) | CDK2PDE10A | |
| SCHEMBL4107784 | 0.73 | TBXAS1 (0.31) | TBXAS1 | |
| SCHEMBL15288383 | 0.70 | CDK2 (0.61) | CDK2PDE10A | |
| SCHEMBL4125812 | 0.69 | ALDH1A1 (0.39) | — | |
| SCHEMBL13657198 | 0.68 | PDE10A (0.35) | CDK2PDE10A | |
| SCHEMBL12953072 | 0.67 | PDE10A (0.46) | CDK2PDE10A | |
| SCHEMBL5489325 | 0.67 | CDK2 (0.38) | CDK2PDE10A | |
| SCHEMBL23994248 | 0.65 | PDE10A (0.43) | CDK2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064214-B1 | Pyrazolo[l,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives useful as protein kinase inhibitors | POLARIS GROUP (TW) | 2013-01-30 | — | — | EP | disclosed |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2009-10-01 | — | — | US | disclosed |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2009-10-01 | — | — | US | disclosed |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2009-10-01 | — | — | US | disclosed |
| EP-2064214-A1 | PYRAZ0L0(L,5-A) (1, 3, 5) TRIAZINE AND PYRAZOLO (1, 5-A) PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | Polaris Group (TW) | 2009-06-03 | — | — | EP | disclosed |
| US-7517882-B2 | Protein kinase inhibitors | POLARIS GROUP (CN) | 2009-04-14 | — | — | US | disclosed |
| US-7517882-B2 | Protein kinase inhibitors | POLARIS GROUP (CN) | 2009-04-14 | — | — | US | disclosed |
| US-7517882-B2 | Protein kinase inhibitors | POLARIS GROUP (CN) | 2009-04-14 | — | — | US | disclosed |
| WO-2008036277-A1 | PYRAZ0L0(L,5-A) (1, 3, 5) TRIAZINE AND PYRAZOLO (1, 5-A) PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008036277-A1 | PYRAZ0L0(L,5-A) (1, 3, 5) TRIAZINE AND PYRAZOLO (1, 5-A) PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2008-03-27 | — | — | WO | disclosed |
| US-20080070893-A1 | Protein Kinase Inhibitors | POLARIS GROUP (CN) | 2008-03-20 | — | — | US | disclosed |
| US-20080070893-A1 | Protein Kinase Inhibitors | POLARIS GROUP (CN) | 2008-03-20 | — | — | US | disclosed |
| US-20080070893-A1 | Protein Kinase Inhibitors | POLARIS GROUP (CN) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070893-A1 | Protein Kinase Inhibitors | MAP3K15, MAP3K20, MAP3K5 | CDK2 43/4885PDE10A 2356/4885ATM 286/4885 |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | MAP3K15, MAP3K20, MAP3K5 | CDK2 43/4885PDE10A 2356/4885ATM 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.